Berwick is a borough in Columbia County, Pennsylvania, United States, 28 miles southwest of Wilkes Barre. As of the 2010 census, Berwick had a population of 10,477. It is one of the two principal communities of the Bloomsburg-Berwick, PA Micropolitan Statistical Area, a micropolitan area that covers Columbia and Montour counties, and had a combined population of 85,562 at the 2010 census.